PhD fellow in Clinical Immunology
Department of Clinical Immunology, Aalborg University Hospital
The Department of Clinical Immunology, Aalborg University Hospital and the Faculty of Health Science at Aalborg University is offering a PhD scholarship in stroke diagnostics commencing 01.05. 2021 or by individual agreement.Description of the department and the scientific environment
Department of Clinical Immunology is the regional department for Clinical Immunology and Transfusion Medicine. The department carries out immunological diagnostics, including inborn immunodeficiencies and autoimmune diseases as well as blood bank management and production of blood products. Research is an integrated part of the department and we have a dedicated group of MSc’s, medical doctors and bioengineers involved in our research group. The research area covers extracellular vesicles, autoimmune diseases, immunodeficiencies, genetic association studies, and cancer immunotherapy.
The department has about 105 employees, including two associate professors, eight medical doctors and six researchers. The department is equipped with modern instruments for molecular and cellular analysis. The department will be located in the New Aalborg University Hospital from 2023.The positions and project descriptions
The research is founded in our existing research in protein microarray as a platform for analysis of extracellular vesicles. The PhD. fellow will be in close collaboration with Department of Chemistry and Bioscience, Aalborg University and CFIN/Mindlab, Aarhus university. On daily basis, the student will be associated to our research laboratory.The PhD. projectSTIMULATE - Stroke diagnostics implementing novel multiparametric test for acute treatment decisions.Background
Ultra-early diagnosis of stroke, originating from either blocked or bleeding blood vessels in the brain, will save time and lead to faster treatment, which is of utmost importance in stroke. Unfortunately, current methods cannot distinguish between stroke types and a reliable diagnosis has to await imaging of the brain at the hospital, delaying the start of treatment.
The STIMULATE project will develop a blood based diagnostic test to distinguish between stroke types. When suffering a stroke, specific extracellular vesicles are released from the stroke area into the blood. Based on these vesicles, we aim to identify biomarkers that can help diagnose stroke type already in the ambulance, leading to better outcome for the patients
The project is part of greater, collaborative program study (ENIGMA) supported by the Novo Nordic Foundation Tandem Program (STIMULATE) and the Lundbeck Foundation.
Read more at: https://www.en.auh.dk/press-room/news-archive/2020/ultra-early-diagnosis-of-stroke-will-lead-to-better-outcome-for-
patients/.Main objectives of the study
- Establish an assay to analyze extracellular vesicles using microarray technology.
- Antibodies will be isolated in vitro, using the technology termed Phage Display, and modified for in solution fast detection of antigens.
Malene Møller Jørgensen, Senior Scientist, Ph.D., Department of Clinical Immunology, Aalborg University
Hospital. Peter Kristensen, Associate Professor, Department of Chemistry and Bioscience, Aalborg University. Kim Ryun Drasbek, CFIN/ Mindlab, Aarhus University.
The position is available for a 3-year period and your key tasks as a PhD student are:
To manage and carry through your research project
- Attend PhD courses
- Write scientific articles and your PhD thesis
- Teach and disseminate your research
- Abroad stay at an external research institution for a few months
We are seeking highly motivated applicants with an MSc degree in biotechnology, molecular biology, medical science, medicine with industrial specialisation or similar related fields with the following competences:
- Theoretical and practical experience with molecular biology, protein chemistry and immune assay.
- Oral examinations and interpretation
- Statistics on advanced level
- Hands-on experience with molecular biology and immune assays.
Good oral and written English competences
It will be highly advantageous to have one or more of the following qualifications:
Salary and terms of employment
- Publications in peer-reviewed scientific journals or knowledge to scientific journal writing
- Experience with scientific work
The salary and terms of employment follow the current agreement between the Ministry of Finance and the union of academics (AC). The average working hours per week is 37 hours.Contact:
Further information can be obtained by senior scientist, Ph.D. Malene Møller Jørgensen, firstname.lastname@example.org.
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