We are looking for one or two talented and motivated PhD students for a project focusing on advanced statistical methods for developing stable mutational signatures as predictive biomarkers for anti-cancer therapy directed towards DNA repair deficient tumours
. The positions will be PhD studies with a three months’ pre-project phase followed by a three-year PhD project. The positions are open from 1 January 2022 or soon hereafter.
The candidates will be enrolled as PhD students at the Doctoral School of the Faculty of Medicine, Aalborg University, in accordance with the regulations of Ministerial Order No.1039 of 27 August 2013 on the PhD Programme at the University and Certain Higher Artistic Educational Institutions after the three months’ pre-project phase.About the position
Aalborg University Hospital has decided to develop its research profile by establishing and funding several Research-CUBES (ForkskningsKUBER) which will strengthen its research profile nationally and internationally. One of the first Research-CUBES is REPAIR.
The aim of REPAIR is to improve the identification and biological understanding of DNA damage repair deficient tumours in selected groups of cancer patients, to optimise diagnostics, prognostics, and treatment decisions. REPAIR is a close collaboration between the Departments of: Molecular Diagnostics, Nuclear Medicine, Clinical Genetics, Pathology, Gynaecology and Obstetrics, Oncology, and Haematology and the North Denmark Region’s Business Intelligence and Analysis Unit. Genomic signatures derived by unsupervised clustering methods have recently gained increasing interest (see e.g., Alexandrov et al., “The repertoire of mutational signatures in human cancer”, Nature 578, 94-101, 2020). These signatures can, however, be unstable due to, e.g., non-uniqueness and high variability. Thus, the purpose of this PhD study is to study the stability of the genomic signatures by advanced statistical modelling, integrating them with other diagnostics, such as histopathology and imaging, and thereby facilitating validation by genome editing techniques and implementation in personalized medicine research protocols. The PhD student will collaborate closely with researchers and PhD students from the other participating departments.
Limited teaching and supervision duties within bioinformatics and biostatistics at the Faculty of Medicine, Aalborg University, may be expected.We offer
We offer a rewarding and challenging job in an interdisciplinary environment. We strive for academic excellence in an environment characterised by collegial respect and academic freedom tempered by responsibility. Qualification requirements
Appointment as PhD student presupposes qualifications at the MSc–level. The research potential of each applicant will be emphasized in the overall assessment.
The application must contain the following
- MSc in statistics, bioinformatics, data science, or a closely related field
- Experience with clinical research
- Experience with methodological development of statistics
- Experience with bioinformatics
- Experience in statistical programming, e.g., R, Stata, Python, or SAS
- Experience with data management and analysis of large data sets
- Motivated by interdisciplinary research
- Excellent writing and communication skills in English with a good scientific vocabulary
About the department
- A motivated text wherein the reasons for applying, qualifications in relation to the position, and intentions and visions for the position are stated
- A current curriculum vitae including publications
- Copies of relevant diplomas (Master of Science)
- Scientific qualifications
- Dissemination qualifications, including participation on committees or boards, participation in organisations and the like
- Additional qualifications in relation to the position
- Personal data
Aalborg University Hospital is one of five highly specialized university hospitals in Denmark. It serves as a cooperation within healthcare between North Denmark Region and the Faculty of Medicine at Aalborg University. The close cooperation between Aalborg University and Aalborg University Hospital ensures health research, education, and innovation at an international level. The Department of Haematology at Aalborg University Hospital and its associated laboratory is an active and ambitious research unit. We are dedicated to research projects in experimental and clinical haematology. The unit was established 16 years ago and has focus on molecular research, clinical epidemiology and real-world data studies, as well as data science. The Clinical Data Science Group, Department of Clinical Medicine, Aalborg University and Department of Haematology, Aalborg University Hospital, works primarily with methodological developments and applications of bioinformatics, biostatistics, machine learning, and data management within clinical research. The research unit is highly interdisciplinary, employing biostatisticians as well as bioinformaticians, software developers, and data managers who work in collaboration with molecular biologists and health care personnel throughout the Danish health care sector. Based on real world health data and molecular biomarkers, the focus is currently on establishing scalable, national decision support tools for personalized medicine in cancer treatment and health economics benefit. The research unit also participates in the Danish National Research Foundation’s Center for Molecular Prediction of Inflammatory Bowels Disease (PREDICT), the Danish Comprehensive Cancer Center’s Research Centre for Precision Medicine in blood cancer, and the Novo Nordisk Foundation supported National Health Data Science Sandbox.Useful information
For further information regarding the position, please contact professor in bioinformatics and statistics, Martin Bøgsted, tel.: +45 5092 5639, email: email@example.com
We expect to conduct job interviews during week 49, 2021. Om Region Nordjylland
Region Nordjylland leverer velfærd til omkring 590.000 nordjyder inden for sundhed, regional udvikling og det specialiserede socialområde. Vi er ca. 15.000 medarbejdere om opgaven, der med et utal af forskellige fagligheder hver dag arbejder for at skabe værdi for de nordjyske patienter og borgere og et sammenhængende Nordjylland. Hos os kan du både gøre karriere, gøre hver dag vigtig og gøre en forskel. Læs mere om regionen på www.rn.dk